The significance of a clean API lies in its simplicity, usability, and ease of integration. Clean APIs are designed to be intuitive, reducing complexity and making it easier for developers to understand and implement their functionalities. They follow consistent naming conventions and clear documentation, enabling faster integration into applications. A clean API enhances user experience and encourages widespread adoption while reducing errors and misunderstandings. By prioritizing clarity and simplicity, organizations can increase developer satisfaction and foster innovation, leading to more robust ecosystems around their products and services.