A Virtual Private Cloud (VPC) in cloud computing refers to a secure, isolated section of a public cloud environment that provides enhanced control over resources. VPC allows users to define a virtualized network topology, including IP addressing, subnets, and security settings. This architecture enables organizations to host applications and store data in a cloud without relinquishing control over their security and compliance needs. Businesses benefit from the scalability of public clouds while maintaining the privacy of a private network, offering a balanced solution for many enterprises.