The significance of studying the metabolism of organisms lies in understanding how they obtain and utilize energy to sustain life. Metabolism encompasses all biochemical processes, including catabolism (breaking down molecules for energy) and anabolism (building complex molecules). Studying metabolism is crucial for several reasons, including insights into disease mechanisms, how organisms adapt to their environments, and the impact of nutrition on health. Metabolic studies also have applications in fields like biotechnology and pharmacology, contributing to the development of therapies and improved agricultural practices.