A biological research methodology refers to the systematic approach used to investigate biological questions and phenomena. Common methodologies include experimentation, observational studies, and modeling. Experiments typically involve controlled conditions to test specific hypotheses, while observational studies look at natural occurrences without intervention. Additionally, modeling can simulate biological processes to predict outcomes. Employing appropriate methodologies allows researchers to gather reliable data, draw conclusions, and advance knowledge in fields such as genetics, ecology, and microbiology.