The major political event associated with the slogan "Hope and Change" is the 2008 U.S. presidential election, when Barack Obama ran as the Democratic candidate. His campaign emphasized optimism and a fresh approach to governance, appealing to voters who sought reform in various areas, including healthcare, the economy, and foreign policy. The slogan resonated with many Americans disillusioned by the previous administration's policies, particularly during the financial crisis. Obama's victory marked a significant moment in U.S. history, highlighting a shift toward a more inclusive political landscape, reflective of the nation’s diversity.