The Separation of Church and State is a fundamental principle that maintains a distinct boundary between religious institutions and government authority. Its significance in politics lies in safeguarding religious freedom and preventing discrimination on the basis of faith. This separation ensures that no particular religion can dictate laws or policies, allowing for a pluralistic society where diverse beliefs coexist. It also protects governance from the influence of religious leaders and dogmas, promoting policies based on rational debate and collective welfare rather than religious mandates. This principle is essential for maintaining democratic integrity.