The tragic fate of Orpheus' wife in Greek mythology is that she, named Eurydice, died from a snake bite shortly after their wedding. Driven by his love for her, Orpheus ventured to the underworld to retrieve her, charming Hades and Persephone with his music. He was granted permission to lead Eurydice back to the living world but was given one condition: he must not look back at her until they reached the surface. However, succumbing to doubt, he glanced back, resulting in Eurydice being lost to him forever. This story underscores themes of love, loss, and the fragility of hope.