The significance of the Treaty of Ghent for the United States lies in its formal end to the War of 1812 and its role in establishing a lasting peace between the U.S. and Britain. Signed in 1814, the treaty restored pre-war boundaries and helped to resolve territorial disputes without substantial territorial changes. It marked a turning point in U.S. foreign policy, affirming the nation's sovereignty and solidifying its existence as a legitimate state. Additionally, the treaty fostered a sense of nationalism and unity after the war, paving the way for future American expansion and growth during the 19th century.