The significant trade route that connected Europe, Africa, and Asia is known as the Transatlantic Trade Route or the Triangular Trade. This route facilitated the exchange of goods, resources, and people among these continents from the 16th to the 19th centuries. It involved the export of manufactured goods from Europe to Africa, the enslavement and transportation of Africans to the Americas for labor, and the shipment of agricultural products like sugar, tobacco, and cotton back to Europe. This complex network had devastating social effects on African societies and laid the groundwork for the economies of the Americas, impacting global trade dynamics.