The endocannabinoid system plays a crucial role in exercise by regulating various physiological processes. During physical activity, the body produces endocannabinoids, which are compounds that enhance pain relief and increase feelings of happiness. This system also contributes to homeostasis, impacting mood, appetite, and sleep patterns. The interaction between exercise and the endocannabinoid system may explain the so-called “runner’s high,” where individuals experience a euphoric feeling post-exercise, promoting mental resilience and emotional well-being.