Prolonged sitting can lead to various negative health effects, including obesity, cardiovascular disease, and musculoskeletal disorders. Extended sedentary behavior can reduce metabolic rate, impacting how the body processes calories. It may also contribute to poor posture and associated pain. Additionally, prolonged sitting is linked to increased risks of diabetes and early death. Incorporating regular breaks and standing or walking during the day can help mitigate these risks and promote overall well-being.