Differences in metabolic responses between men and women are attributed to hormonal variations, body composition, and energy needs. Generally, men have a higher metabolic rate due to greater muscle mass, which burns more calories at rest compared to women. Hormones like testosterone play a significant role in muscle development and fat distribution. Women, on the other hand, may exhibit different fat utilization patterns during exercise and require fewer calories due to typically lower muscle mass. These disparities can influence exercise and nutrition strategies, necessitating tailored approaches for effectively managing weight and achieving fitness goals in both genders.