During weight loss, the body responds to caloric deficits by altering its metabolism and prioritizing energy use. Initially, it utilizes stored glycogen and fat for energy; however, prolonged deficits can lead to muscle loss as the body seeks alternative energy sources. Hormonal changes, such as decreased levels of leptin and increased ghrelin, may also occur, influencing hunger and satiety signals. Consequently, understanding these responses is critical for sustainable weight loss and effectively managing caloric intake.