The major river that flows through Berlin is the Spree River. This river is integral to the city's history and development, as it meanders through the heart of Berlin and numerous neighborhoods. The Spree has been a vital trade route since medieval times and contributes to the city's picturesque landscape. Along its banks, visitors can explore various parks, museums, and historical sites. The river's cultural significance is highlighted by boat tours and waterfront activities, making it an attractive feature of Berlin's urban environment.