The organ in the human body primarily responsible for detoxifying substances is the liver. The liver performs a wide range of vital functions, including metabolizing nutrients, processing drugs, and filtering blood to remove toxins. It converts harmful substances into less toxic forms and ensures detoxified waste is excreted through bile or urination. Moreover, the liver plays a pivotal role in regulating metabolism, blood sugar levels, and overall homeostasis. A healthy liver is essential for maintaining overall well-being and optimal bodily function.