The strategic significance of prioritizing topics during UPSC exam preparation lies in efficiently allocating time and resources to high-yield areas. Candidates should focus on topics that carry more weight in the syllabus or have frequently appeared in past papers. Prioritization enables efficient management of study sessions, ensuring that crucial subjects receive appropriate attention. Creating a timeline or checklist for all topics can help systematically cover the syllabus while identifying weaker areas for further focus. This strategy also reduces stress by creating manageable goals.