Aspirants can effectively deal with negative marking in UPSC exams by implementing a few key strategies. Firstly, they should focus on accuracy over speed, ensuring they answer only questions they are confident about. Developing a strong grasp of the syllabus and question patterns through previous year papers can help in identifying high-yield areas. Regular mock tests can enhance time management and decision-making skills. Lastly, creating a strategy for guessing can minimize losses, allowing students to weigh the risk of unsure answers judiciously.