Aspirants can effectively address negative marking in the UPSC Preliminary Examination through strategic practices. First, understanding the test structure allows candidates to prioritize certainty over guessing, focusing on questions they are confident about. Employing methods such as careful time management ensures they do not rush through questions, reducing mistakes. Additionally, practicing with previous years' papers can help candidates gauge their strength and weaknesses, allowing targeted preparation. Finally, using mock tests to simulate exam conditions can aid in developing a calm, focused mindset, ultimately enhancing overall performance and minimizing potential penalties from incorrect answers.