The first female Secretary of State in the U.S. was Madeleine Albright, who held the position from 1997 to 2001 under President Bill Clinton. A trailblazer in U.S. foreign policy, Albright played a significant role in shaping international relations, advocating for human rights, and promoting democracy worldwide. Her tenure marked a pivotal point in U.S. political history, emphasizing the importance of women in leadership.