The major influences on the works of Pablo Picasso include African art, Cubism, and personal experiences. His early works were inspired by the Blue and Rose Periods, reflecting his emotions and social observations. Picasso's exposure to African masks influenced his innovative style, leading to the development of Cubism alongside Georges Braque. His versatility and willingness to experiment reshaped artistic expression, making him one of the most significant artists of the 20th century.