Comedian Chelsea Handler faced numerous struggles while rising to fame, including navigating the entertainment industry as a female comedian. She dealt with issues such as gender inequality and the constant need to prove herself in a predominantly male-dominated field. Handler also encountered personal challenges, including the loss of her brother and her past difficulties with substance abuse. These experiences informed her comedic style, enabling her to deliver humor infused with honesty and vulnerability. Her candidness about these struggles resonated with audiences and allowed her to carve out a unique and influential space in comedy, ultimately leading to successful shows like “Chelsea Lately.”