Harriet Beecher Stowe faced numerous challenges that shaped her writing of "Uncle Tom's Cabin." As a woman in the 19th century, she navigated societal expectations while passionately advocating for abolition. Stowe's encounters with the realities of slavery during her time in Kentucky exposed her to the harsh conditions faced by enslaved people. The loss of her own son further fueled her emotional drive to write about human rights. Stowe's critique of societal norms and her use of empathy and moral persuasion resonated with readers, bolstering the abolitionist movement and leaving a lasting impact on American literature.