Harriet Beecher Stowe's contributions significantly impacted the anti-slavery movements in the United States, particularly through her novel "Uncle Tom's Cabin." Published in 1852, the book illuminated the harsh realities of slavery and humanized enslaved individuals, galvanizing public sentiment against the institution. Stowe's vivid storytelling and emotional depth prompted widespread discussions on morality and justice, significantly influencing the abolitionist movement. Her work helped to sway public opinion in the North and raised awareness about the cruelties of slavery, ultimately contributing to the societal changes that led to the Civil War and the eventual emancipation of enslaved people in America.